In our research, we study how the architecture of the brain supports the remarkable array of flexbile cognition and memory behavior in humans. To do this, we use the tools of functional and anatomical neuroimaging to peer into the human brain, combined with computational modeling of neural circuits and behaviors, and analyses of large-scale neurophysiological data. Uncovering the principles of higher-order cognition and memory is imperative, as these processes are disrupted across an array of neuropsychiatric disorders. Knowledge about working memory circuits will be critical for developing next-generation, targeted interventions and in broadly advancing human cognitive and brain health.